Publications & Patents

Ponce-Díaz FJ, Cerero-Tejero L, García-Martín A, Salamone S, Pollastro F, Appendino G, Guimaré JA, Gómez-Cañas M, Fernández-Ruiz J, Vega J, Del Olmo E, Feliciano AS, Muñoz E. Allosteric Modulation of the CB1 Receptor by a Juniper Berry Seasoning Extract: Deoxypodophyllotoxin as the Major Active Constituent. J Agric Food Chem. 2026; 74(33):26221-26235.

García-Martín A, Prados ME, Lastres-Cubillo I, Ponce-Diaz FJ, Cerero L,Garrido-Rodríguez M, Navarrete C, Pineda R, Rodríguez AB, Muñoz I, Moya J, Medeot A, Moreno JA, Chacón A, García-Revillo J, Muñoz E. Etrinabdione (VCE-004.8), a B55α activator, promotes angiogenesis and arteriogenesis in critical limb ischemia. J Transl Med. 2024; 22(1):1003.

Lavayen BP, Yang C, Larochelle J, Liu L, Tishko RJ, de Oliveira ACP, Muñoz E, Candelario-Jalil E. Neuroprotection by the cannabidiol aminoquinone VCE-004.8 in experimental ischemic stroke in mice. Neurochem Int. 2023;165:105508.

Navarrete C, García-Martín A, Correa-Sáez A, Prados ME, Fernández F, Pineda R, Mazzone M, Álvarez-Benito M, Calzado MA, Muñoz E. A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury. J Neuroinflammation. 2022;19(1):177.

Navarrete C, García-Martin A, Garrido-Rodríguez M, Mestre L, Feliú A, Guaza C, Calzado MA, Muñoz E. Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis. Neurobiol Dis. 2020; 143:104994.

Caprioglio D, Mattoteia D, Pollastro F, Negri R, Lopatriello A, Chianese G, Minassi A, Collado JA, Munoz E, Taglialatela-Scafati O, Appendino G. The Oxidation of Phytocannabinoids to Cannabinoquinoids. J Nat Prod. 2020; 83(5):1711-1715.

Appendino G, DeMesa J, Muñoz E. The endocannabinoid system of the skin. A potential approach for the treatment of skin disorders. Biochem Pharmacol. 2018; 157:122-133.

García-Martín A, Garrido-Rodríguez M, Navarrete C, Del Río C, Bellido ML, Appendino G, Calzado MA, Muñoz E. EHP-101, an oral formulation of the cannabidiol aminoquinone VCE-004.8, alleviates bleomycin-induced skin and lung fibrosis. Biochem Pharmacol. 2018; 157:304-313.

Navarrete C, Carrillo-Salinas F, Palomares B, Mecha M, Jiménez-Jiménez C, Mestre L, Feliú A, Bellido ML, Fiebich BL, Appendino G, Calzado MA, Guaza C, Muñoz E. Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy. J Neuroinflammation.2018;15(1):64.

Muñoz Blanco E, Lastres-Cubillo I, García Martín A, inventors; Universidad de Córdoba, Servicio Andaluz de Salud, applicants. Cannabinoid aminoquinone compounds as activators of AMPK/Sirtuin-1 pathway. International patent application PCT/EP2025/053266. Publication WO 2025/168780 A1. 2025 Aug 14. European application EP25706303.2.